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(27) E. Lakatos, M.J. Williams et al., Evolutionary dynamics of neoantigens in growing tumours. Nature Genetics (2020). PDF

(26) G. Caravagna, T. Heide et al., Subclonal reconstruction of tumors by using machine learning and population genetics. Nature Genetics  52, 898-907 (2020). PDF

(25) A. Acar, D. Nichol et al., Exploiting evolutionary steering to induce collatoral drug sensitivity in cancer. Nature Communications  11, 1923 (2020). PDF

(24) M. Williams, L.Zapata, B. Werner et al., Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios. eLife  9,e48714 (2020). PDF

(23) B. Werner, J. Case, M.J. Williams et al., Measuring single cell divisions in human tissues from multi-region sequencing data. Nature Communications  11, 1035 (2020). PDF

(22) C. Retel, V. Kowallik, W. Huang, B. Werner, S. Künzel, L. Becks & P.G.D. Feulner, The feedback between selection and demography shapes genomic diversity during coevolution. Science Advances  5, eaax0530 (2019)PDF

(21) K. Chkhaidze, T. Heide, B. Werner et al., Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data. PLoS Comput. Biol.  15 , e1007243 (2019)PDF

(20) L. Opasic, D. Zhou, B. Werner, D. Dingli & A. Traulsen, How many samples are needed to infer truly clonal mutations from heterogenous tumours? BMC Cancer 19, 403 (2019)PDF

(19) I. Spiteri, G. Caravagna et al., Evolutionary dynamics of residual disease in human glioblastoma. Annals of Oncology, 1-8 (2018)PDF

(18) K.H. Khan, D. Cunningham, B. Werner et al., Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Clinical Trail. Cancer Discovery 8, 1-16 (2018)PDF

(17) M. A. Böttcher, D. Dingli, B. Werner & A. Traulsen, Replicative cellular age distributions in compartmentalized tissues. Journal of the Royal Society Interface 15: 20180272 (2018)PDF

(16) B. Werner & A. Sottoriva, Variation of mutational burden in healthy tissues suggests non-random strand segregation and allows measuring somatic mutation rates. PLoS Comput. Biol. 14, e1006233 (2018)PDF

(15) M.J. Williams, B. Werner, T, Heide, C. Curtis, C.P. Barnes, A. Sottoriva & T. Graham, Quantification of subclonal selection in cancer from bulk sequencing data. Nature Genetics 50, 895-903 (2018)PDF

(14) W. Huang, A. Traulsen, B. Werner, T. Hiltunen & L. Becks, Dynamical trade-offs arise from antagonistic coevolution and decrease intraspecific diversity. Nature Communications 8:2059 (2017)PDF

(13) B. Werner, A. Traulsen, A. Sottoriva & D. Dingli, Detecting truly clonal alterations from multi-region profiling of tumours. Scientific Reports, 7:44991 (2017)PDF

(12) H. Lote et al., Carbon dating cancer: defining the chronology of metastatic progression of colorectal cancer. Annals of Oncology (2017)PDF

(11) L. Hindersin, B. Werner, d. Dingli & A. Traulsen, Should tissue structure suppress or amplify selection to minimize cancer risk? Biology Direct 11, 1-11 (2016)PDF

(10) B. Werner et al., The Cancer Stem Cell Fraction in Hierarchically Organized Tumours Can Be Estimated Using Mathematical Modeling and Patient-Specific Treatment Trajectories. Cancer Research 76, 1705-1713 (2016).PDF

(9) M.J Williams, B. Werner, C.P. Barnes, T.A. Graham & A. Sottoriva, Identification of neutral tumour evolution across cancer types. Nature Genetics 48, 238-244 (2016)PDF

(8) B. Werner, A. Traulsen & D. Dingli, Ontogenic growth as root of fundamental differences bewteen childhood and adult cancer. Stem Cells 34, 543-550 (2015)PDF

(7) B. Werner et al., Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions. eLife e0867v2. (2015)PDF

(6) B. Werner et al., Dynamics of Leukemia Stem-like Cell Extinction in Acute Promyelocytic Leukemia. Cancer Research 74, 5386-5396 (2014)PDF

(5) R. Schulz, B. Werner & U. Behn, Self-tolerance in a minimal model of the idiotypic network. Frontiers In   Immunology 5, 103-114 (2014)PDF

(4) B. Werner, D. Dingli & A. Traulsen, A deterministic model for the occurence and dynamics of multiple mutations in hierachically organized tissues. Journal of the Royal Society Interface 10, 20130349 (2013)PDF

(3) W. Huang, B. Werner & A. Traulsen, The impact of random frequency-dependent mutations on the average population fitness. BMC Evolutionary Biology 12, 1-10 (2012)PDF

(2) B. Werner et al., Dynamics of Resistance Development to Imatinib under increasing Selection Pressure: A combination of Mathematical Models and In Vitro Data. PLoS ONE 6, e28955 (2011)PDF

(1) B. Werner, D. Dingli, T. Lenaerts, J.M. Pacheco & A. Traulsen, Dynamics of Mutant Cells in Hierarchically Organized Tissues. PLoS Comput. Biol. 7, e1002290 (2011).  PDF

© Benjamin Werner 2019