Publications


  1.  B. Werner, D. Dingli, T. Lenaerts, J. M. Pacheco, A. Traulsen, Dynamics of Mutant Cells in Hierarchical Organized Tissues. PLoS Comput Biol. 7, e1002290. (2011) PDF
  2. B. Werner, D. Lutz, T. H. Brümmendorf, A. Traulsen, S. Balabanov, Dynamics of Resistance Development to Imatinib under Increasing Selection Pressure: A Combination of Mathematical Models and In Vitro Data. PLoS ONE. 6, e28955 (2011)PDF
  3. W. Huang, B. Werner, A. Traulsen, The impact of random frequency-dependent mutations on the average population fitness. BMC Evolutionary Biology. 12, 1–10. (2012) PDF
  4. B. Werner, D. Dingli, A. Traulsen, A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues. Journal of The Royal Society Interface. 10, 20130349. (2013) PDF
  5. R. Schulz, B. Werner, U. Behn, Self-tolerance in a minimal model of the idiotypic network. Frontiers in Immunology. 5, 103–114. (2014) PDF
  6. B. Werner et al., Dynamics of Leukemia Stem-like Cell Extinction in Acute Promyelocytic Leukemia. Cancer Research. 74, 5386–5396. (2014) PDF
  7.  B. Werner et al., Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions. eLife. 10.7554, e08687v2. (2015) PDF
  8. B. Werner, A. Traulsen, D. Dingli, Ontogenic growth as the root of fundamental differences between childhood and adult cancer. Stem Cells. 34, 543–550. (2015)  PDF
  9.  M. J. Williams, B. Werner, C. P. Barnes, T. A. Graham, A. Sottoriva, Identification of neutral tumor evolution across cancer types. Nature Genetics. 48, 238–244. (2016) PDF
  10. B. Werner et al., The Cancer Stem Cell Fraction in Hierarchically Organized Tumors Can Be Estimated Using Mathematical Modeling and Patient-Specific Treatment Trajectories. Cancer Research. 76, 1705–1713. (2016) PDF
  11.  M. J. Williams, B. Werner, T. A. Graham, A. Sottoriva, Functional versus non-functional intra-tumor heterogeneity in cancer. Molecular & Cellular Oncology. 3, e1162897. (2016)
  12.  L. Hindersin, B. Werner, D. Dingli, A. Traulsen, Should tissue structure suppress or amplify selection to minimize cancer risk? Biology Direct. 11, 1–11. (2016)  PDF
  13. H. Lote et al., Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer. Annals of Oncology. (2017). PDF
  14. B. Werner, A. Traulsen, A. Sottoriva, D. Dingli, Detecting truly clonal alterations from multi-region profiling of tumours.  Scientific Reports, 7:44991 (2017). PDF
  15. W. Huang, A. Traulsen, B. Werner, T. Hiltunen, L. Becks, Dynamical trade-offs arise from antagonistic coevolution and decrease intraspecific diversity. Nature Communications 8:2059 (2017).  PDF
  16. M. J. Williams, B. Werner, T. Heide, C. Curtis, C. P. Barnes, A. Sottoriva, T. A. Graham, Quantification of subclonal selection in cancer from bulk sequencing data. Nature Genetics. 50, 895-903 (2018). PDF
  17. B. Werner, A. Sottoriva. Variation of mutational burden in healthy tissues suggests non-random strand segregation and allows measuring somatic mutation rates. PLoS Comput. Biol. 14, e1006233 (2018). PDF
  18. M.A. Böttcher, D.Dingli, B. Werner, A. Traulsen, Replicative cellular age distributions in compartmenalized tissues. Journal of the Royal Society Interface. 15: 20180272 (2018). PDF  
  19. K.H. Khan, D. Cunningham, B. Werner et al., Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial. Cancer Discovery, 8, 1-16, (2018). PDF 
  20. I. Spiteri, G. Caravagna, G.D. Cresswell et al., Evolutionary dynamics of residual disease in human glioblastoma. Annals of Oncology 0, 1-8 (2018). PDF


© Benjamin Werner 2016